- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Inflammatory Myopathy with Severe Tongue Atrophy in Pembroke Welsh Corgi Dogs
-
- Kaoru Toyoda
- Departments of Veterinary Pathology
-
- Kazuyuki Uchida
- Departments of Veterinary Pathology
-
- Naoaki Matsuki
- Veterinary Clinical Pathobiology
-
- Hideo Sakai
- Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo; Isahaya Pet Clinic, Isahaya, Nagasaki, Japan
-
- Masato Kitagawa
- Laboratory Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan
-
- Miyoko Saito
- Department of Veterinary Surgery, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan
-
- Jun Sasaki
- Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo; Isahaya Pet Clinic, Isahaya, Nagasaki, Japan
-
- Hiroyuki Nakayama
- Departments of Veterinary Pathology
Search this article
Description
<jats:p>A disease characterized by tongue and facial muscle atrophy has been recognized sporadically among Pembroke Welsh Corgi (PWC) dogs in Japan. The present study describes the pathologic findings of this canine syndrome. Histopathologic examinations were performed in 2 dogs, including a case of muscular biopsy. Identification and characterization of autoantibodies were attempted by fluorescent antibody test (FAT) and Western blot (WB) by using sera from 7 PWC dogs with typical clinical features, 6 PWC dogs with other clinical signs, and 2 from other breeds with polymyositis. Clinically, the 7 affected PWC dogs exhibited dysphagia with severe tongue atrophy, facial muscular atrophy, and occasional walking difficulty. Histopathologic examinations of the 2 dogs with clinical symptoms revealed moderate to severe inflammatory lesions characterized by lymphohistiocytic infiltration and muscular atrophy in the tongue and/or femoral muscles. The tongue lesions were very severe and accompanied by diffuse fatty infiltration. There were no major lesions in the nervous tissues examined. By FAT, an autoantibody against the cross striation of skeletal muscle was detected in sera from 5 affected PWC dogs. By using WB analysis, the autoantibodies recognized a 42-kDa molecule in striated muscle but not in the nervous tissues. All of the findings indicated that the unique disease of PWC dogs might be generalized inflammatory myopathy, whereas the detailed etiology concerning the dominant involvement of tongue muscles and the role of the autoantibody in the canine disease remain to be clarified.</jats:p>
Journal
-
- Journal of Veterinary Diagnostic Investigation
-
Journal of Veterinary Diagnostic Investigation 22 (6), 876-885, 2010-11
SAGE Publications