Highly Mesoporous Metal‐Organic Frameworks as Synergistic Multimodal Catalytic Platforms for Divergent Cascade Reactions
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- Soumen Dutta
- Center for Nanospace-confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
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- Nitee Kumari
- Center for Nanospace-confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
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- Sateesh Dubbu
- Center for Nanospace-confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
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- Sun Woo Jang
- Center for Nanospace-confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
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- Amit Kumar
- Center for Nanospace-confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
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- Hiroyoshi Ohtsu
- Department of Chemistry School of Science Tokyo Institute of Technology Tokyo 152-8550 Japan
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- Junghoon Kim
- Department of Chemistry Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
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- Seung Hwan Cho
- Department of Chemistry Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
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- Masaki Kawano
- Department of Chemistry School of Science Tokyo Institute of Technology Tokyo 152-8550 Japan
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- In Su Lee
- Center for Nanospace-confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea
書誌事項
- 公開日
- 2020-02-03
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/anie.201916578
- 10.1002/ange.201916578
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Rational engineering and assimilation of diverse chemo‐ and biocatalytic functionalities in a single nanostructure is highly desired for efficient multistep chemical reactions but has so far remained elusive. Here, we design and synthesize multimodal catalytic nanoreactors (MCNRs) based on a mesoporous metal‐organic framework (MOF). The MCNRs consist of customizable metal nanocrystals and stably anchored enzymes in the mesopores, as well as coordinatively unsaturated cationic metal MOF nodes, all within a single nanoreactor space. The highly intimate and diverse catalytic mesoporous microenvironments and facile accessibility to the active site in the MCNR enables the cooperative and synergistic participation from different chemo‐ and biocatalytic components. This was shown by one‐pot multistep cascade reactions involving a heterogeneous catalytic nitroaldol reaction followed by a [Pd/lipase]‐catalyzed chemoenzymatic dynamic kinetic resolution to yield optically pure (>99 % ee) nitroalcohol derivatives in quantitative yields.</jats:p>
収録刊行物
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- Angewandte Chemie International Edition
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Angewandte Chemie International Edition 59 (9), 3416-3422, 2020-02-03
Wiley