Advances in DNA Origami–Cell Interfaces

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  • Shubham Mishra
    Department of Chemistry Graduate School of Science Institute for Integrated Cell-Material Sciences Kyoto University Kitashirakawa-Oiwakecho Kyoto 606-8502 Japan
  • Yihong Feng
    Department of Chemistry Graduate School of Science Institute for Integrated Cell-Material Sciences Kyoto University Kitashirakawa-Oiwakecho Kyoto 606-8502 Japan
  • Masayuki Endo
    Department of Chemistry Graduate School of Science Institute for Integrated Cell-Material Sciences Kyoto University Kitashirakawa-Oiwakecho Kyoto 606-8502 Japan
  • Hiroshi Sugiyama
    Department of Chemistry Graduate School of Science Institute for Integrated Cell-Material Sciences Kyoto University Kitashirakawa-Oiwakecho Kyoto 606-8502 Japan

Description

<jats:title>Abstract</jats:title><jats:p>The nascent field of DNA nanotechnology has undergone rapid growth since its inception. By using DNA as a biologically “safe” material, DNA nanotechnology shows great promise in applications such as drug‐delivery systems. Further progress, however, relies on understanding the different ways in which DNA nanostructures behave in and interact with cells, tissues and even whole organisms. Moreover, this knowledge must then be harnessed in innovative ways to improve existing DNA nanostructures and design new ones, so that they can perform more diverse functions more effectively. There have been many developments in this regard in the past few years, and herein some of these are highlighted, with respect to both works that improve our understanding of what happens to DNA nanostructures once they are at their target site, and those that utilise clever design to accomplish desired functions.</jats:p>

Journal

  • ChemBioChem

    ChemBioChem 21 (1-2), 33-44, 2019-11-06

    Wiley

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