Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation
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- Daisuke Maeda
- Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;
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- Tateki Kubo
- Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;
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- Koichiro Kiya
- Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;
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- Kenichiro Kawai
- Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan;
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- Shinsuke Matsuzaki
- Department of Pharmacology, Wakayama Medical University, Kimiidera, Wakayama, Japan;
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- Daichi Kobayashi
- Department of Pharmacology, Wakayama Medical University, Kimiidera, Wakayama, Japan;
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- Toshihiro Fujiwara
- Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan;
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- Taiichi Katayama
- Department of Child Development and Molecular Brain Science, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan
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- Ko Hosokawa
- Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;
書誌事項
- 公開日
- 2019-05-08
- 資源種別
- journal article
- DOI
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- 10.1080/2000656x.2019.1612752
- 公開者
- Medical Journals Sweden AB
この論文をさがす
説明
Excess scar formation can occur after skin injurふy and lead to abnormal scar formation, such as keloids and hypertrophic scars, which are characterised by substantial deposition of extracellular matrix in the dermis. Periostin, an extracellular matrix protein that plays a crucial role in skin development and maintaining homeostasis, is also involved in skin disorders such as systemic/limited scleroderma, wound closure, and abnormal scar formation. However, the mechanism of periostin involvement in abnormal scar formation is not yet fully understood. In this study, we investigated the mechanism by which periostin is involved in abnormal scar formation. Treatment of human dermal fibroblasts (HDFs) with IL-4 and IL-13, which are cytokines of Th2 type immune responses that are up-regulated in abnormal scars, dramatically elevated the levels of periostin mRNA and protein, and also promoted the secretion of periostin by HDFs. Transforming growth factor-β1 (TGF-β1) had the same effect on HDFs as IL-4 and IL-13. Stimulation of HDFs with periostin promoted RhoA/ROCK pathway-mediated TGF-β1 secretion from HDFs. Our results suggest that IL-4 and IL-13 induce periostin expression and secretion, and in turn, secreted periostin induces RhoA/ROCK pathway-mediated TGF-β1 secretion. Secreted TGF-β1 then induces further periostin production and secretion, thereby promoting abnormal scar formation.
収録刊行物
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- Journal of Plastic Surgery and Hand Surgery
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Journal of Plastic Surgery and Hand Surgery 53 (5), 288-294, 2019-05-08
Medical Journals Sweden AB
