Value and limitation of conization as a diagnostic procedure for cervical neoplasm
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- Rumiko Yamamoto
- Department of Obstetrics and Gynecology Kitano Hospital, The Tazuke Kohukai Medical Research Institute Osaka Japan
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- Kentaro Sekiyama
- Department of Obstetrics and Gynecology Kitano Hospital, The Tazuke Kohukai Medical Research Institute Osaka Japan
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- Toshihiro Higuchi
- Department of Obstetrics and Gynecology Kitano Hospital, The Tazuke Kohukai Medical Research Institute Osaka Japan
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- Masae Ikeda
- Department of Obstetrics and Gynecology Tokai University School of Medicine Isehara Japan
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- Mikio Mikami
- Department of Obstetrics and Gynecology Tokai University School of Medicine Isehara Japan
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- Yoichi Kobayashi
- Department of Obstetrics and Gynecology Kyorin University School of Medicine Mitaka‐shi Japan
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- Satoru Nagase
- Department of Obstetrics and Gynecology Yamagata University, Faculty of Medicine Yamagata‐shi Japan
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- Masatoshi Yokoyama
- Department of Obstetrics and Gynecology Saga University Hospital Saga‐shi Japan
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- Takayuki Enomoto
- Department of Obstetrics and Gynecology Niigata University Medical School Niigata‐shi Japan
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- Hidetaka Katabuchi
- Department of Obstetrics and Gynecology, Faculty of Life Science Kumamoto University Kumamoto‐shi Japan
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説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>In the recent years, the number of cervical conization procedures performed for diagnostic or therapeutic purposes is increasing, accompanied by increased cervical neoplasia among young women. This study aimed to analyze the clinical data of patients who underwent conization in Japan.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Among the 14 832 cases of conization registered in 205 facilities over 2 years (2009–2011), the data of 2409 and 12 417 patients who underwent conization for diagnostic and therapeutic purposes, respectively, were retrospectively analyzed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The median age of the patients in diagnostic and therapeutic conization groups was 44 and 37 years, respectively. When comparing the diagnostic and therapeutic groups, 25.5% of the patients in the former were suspected with invasive cancer preoperatively, which is higher than that in the latter (2.7%). About 25.7% in the diagnostic and 14.1% in the therapeutic group had positive margin in the conization specimens. Additional treatment was required for 36.0% and 5.5% of the patients in the diagnostic and therapeutic groups, respectively, which are high figures for both. The risk factors of pathological upgrade in the conization specimens were diagnostic purpose, postmenopausal status and glandular lesion. Additional hysterectomy was performed in 1304 patients after conization, and pathological diagnosis was upgraded in 550 cases. Multivariate analysis revealed that postmenstrual status was an independent risk factor.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This study revealed that cervical lesions of glandular lineage and patients with postmenopausal status benefit from diagnostic conization. However, in postmenopausal patients, the underlying disease cannot be excluded in the preserved uterus even by diagnostic conization.</jats:p></jats:sec>
収録刊行物
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- Journal of Obstetrics and Gynaecology Research
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Journal of Obstetrics and Gynaecology Research 45 (12), 2419-2424, 2019-10
Wiley
