A Point Mutation in <i>carR</i> Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription

DOI Web Site 被引用文献2件 参考文献42件 オープンアクセス
  • Prosenjit Samanta
    Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Rahul Shubhra Mandal
    Biomedical Informatics Center, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Rudra Narayan Saha
    Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Sreeja Shaw
    Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Priyanka Ghosh
    Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Shanta Dutta
    Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Amit Ghosh
    Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Daisuke Imamura
    Okayama University, Okayama, Japan
  • Masatomo Morita
    Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
  • Makoto Ohnishi
    Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
  • Thandavarayan Ramamurthy
    Center for Human Microbial Ecology, Translational Health Science and Technology Institute, Faridabad, India
  • Asish Kumar Mukhopadhyay
    Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India
  • Manuela Raffatellu
    editor

書誌事項

公開日
2020-04-20
資源種別
journal article
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/iai.00080-20
公開者
American Society for Microbiology

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説明

<jats:p> Antimicrobial peptides play an important role in host defense against <jats:named-content content-type="genus-species">Vibrio cholerae</jats:named-content> . Generally, the <jats:named-content content-type="genus-species">V. cholerae</jats:named-content> O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strains has been reported in recent years, including in the devastating Yemen cholera outbreak during 2016-2018. To investigate the factor(s) responsible for the shift in the trend of sensitivity to PB, we studied the two-component system encoded by <jats:italic>carRS</jats:italic> , regulating the lipid A modification of El Tor vibrios, and found that only <jats:italic>carR</jats:italic> contains a single nucleotide polymorphism (SNP) in recently emerged PB-sensitive strains. </jats:p>

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