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- Arup Podder
- Department of Chemistry, Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang 37673 , Korea
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- Ha Jung Lee
- Department of Chemistry, Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang 37673 , Korea
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- Byeang Hyean Kim
- Department of Chemistry, Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang 37673 , Korea
説明
<jats:title>Abstract</jats:title> <jats:p>Modified nucleic acids have a wide range of applications in many areas of biochemistry. In particular, fluorescence-based nucleic acid systems have been studied extensively for their implementation in molecular biology as platforms for disease diagnosis. In this Account, we summarize the past two decades of our research efforts associated with fluorescent nucleic acid systems for bio-sensing. We discuss single-nucleotide polymorphism–based molecular systems and their fluorescence behaviors in duplex DNA; the effects of fluorophore labeling on the fluorescence signals of modified oligonucleotides; pH-responsive nucleic acid–modified fluorescence biosensors; the use of double-stranded DNA and three-way junction–based molecular beacons (MBs) for the detection of biologically important mRNA and miRNA; quencher-free MBs and their applications in vivo; biologically significant G-quadruplex structures and i-motif–based fluorescent biosensors; the detection of trinucleotide repeats; and, finally, some other applications of modified nucleosides with unique properties.</jats:p>
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 94 (3), 1010-1035, 2020-12-25
Oxford University Press (OUP)
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詳細情報 詳細情報について
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- CRID
- 1360287595718208384
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- NII論文ID
- 130008021827
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- ISSN
- 13480634
- 00092673
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