Chemical Insights into Liquid-Liquid Phase Separation in Molecular Biology

  • Yugo R Kamimura
    Graduate School of Pharmaceutical Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 , Japan
  • Motomu Kanai
    Graduate School of Pharmaceutical Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 , Japan

抄録

<jats:title>Abstract</jats:title> <jats:p>Liquid-liquid phase separation (LLPS) in living organisms is a recently emerging biologic principle that may dramatically alter current perceptions of cellular systems. Various proteins, RNAs, and other biomolecules undergo LLPS, exhibiting various cellar functions. The field is still immature, however, there is no consensus regarding the basic experimental techniques used for characterizing the phenomenon, knowledge of the physicochemical basis driving and regulating LLPS in cells is insufficient, and very little is known about potential chemical interventions for LLPS. Addressing these deficiencies requires chemical approaches, and will markedly advance drug discovery, molecular biology, and medicine. Here, we introduce the basic biology of LLPS and present challenges in the field from a chemical viewpoint.</jats:p>

収録刊行物

被引用文献 (10)*注記

もっと見る

参考文献 (105)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ