Mice derived from <i>in vitro</i> αMEM-cultured preimplantation embryos exhibit postprandial hyperglycemia and higher inflammatory gene expression in peripheral leukocytes

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  • Shiori Ishiyama
    Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan
  • Mayu Kimura
    Graduate School of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan
  • Nodoka Umihira
    Graduate School of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan
  • Sachi Matsumoto
    Graduate School of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan
  • Atsushi Takahashi
    Graduate School of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan
  • Takao Nakagawa
    Kiwa Laboratory Animals Co., Ltd., Kiminocho, Wakayama, Japan
  • Teruhiko Wakayama
    Graduate School of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan
  • Satoshi Kishigami
    Graduate School of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan
  • Kazuki Mochizuki
    Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan

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<jats:title>ABSTRACT</jats:title> <jats:p>We examined whether peripheral leukocytes of mice derived from in vitro αMEM-cultured embryos and exhibiting type 2 diabetes had higher expression of inflammatory-related genes associated with the development of atherosclerosis. Also, we examined the impact of a barley diet on inflammatory gene expression. Adult mice were produced by embryo transfer, after culturing two-cell embryos for 48 h in either α minimal essential media (α-MEM) or potassium simplex optimized medium control media. Mice were fed either a barley or rice diet for 10 weeks. Postprandial blood glucose and mRNA levels of several inflammatory genes, including Tnfa and Nox2, in blood leukocytes were significantly higher in MEM mice fed a rice diet compared with control mice. Barley intake reduced expression of S100a8 and Nox2. In summary, MEM mice exhibited postprandial hyperglycemia and peripheral leukocytes with higher expression of genes related to the development of atherosclerosis, and barley intake reduced some gene expression.</jats:p>

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