The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Justin Lamb, Emily D. Crawford, David Peck, Joshua W. Modell, Irene C. Blat, Matthew J. Wrobel, Jim Lerner, Jean-Philippe Brunet, Aravind Subramanian, Kenneth N. Ross, Michael Reich, Haley Hieronymus, Guo Wei, Scott A. Armstrong, Stephen J. Haggarty, Paul A. Clemons, Ru Wei, Steven A. Carr, Eric S. Lander, Todd R. Golub

doi:10.1126/science.1132939

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

DOI Web Site 被引用文献91件

Justin Lamb

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Emily D. Crawford

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
David Peck

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Joshua W. Modell

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Irene C. Blat

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Matthew J. Wrobel

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Jim Lerner

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Jean-Philippe Brunet

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Aravind Subramanian

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Kenneth N. Ross

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Michael Reich

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Haley Hieronymus

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Guo Wei

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Scott A. Armstrong

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Stephen J. Haggarty

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Paul A. Clemons

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Ru Wei

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Steven A. Carr

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Eric S. Lander

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Todd R. Golub

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.

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説明

<jats:p>To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.</jats:p>