Square wave voltammetric sensing of uric acid using the self-assembly of mercaptobenzimidazole

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公開日
2002-08-13
DOI
  • 10.1039/b206703j
公開者
Royal Society of Chemistry (RSC)

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説明

The self-assembled monolayer of a heterocyclic thiol, mercaptobenzimidazole (MBI) on gold (Au) electrode is successfully utilized for the voltammetric sensing of uric acid (UA). The self-assembly of MBI separates the voltammetric signal of UA from the interfering ascorbate (AA). Selective detection of UA in the presence of a large excess of AA or the simultaneous detection of UA and AA is achieved at the MBI monolayer-modified electrode. This electrode can detect as low as 1 microM of UA in the presence of 100-fold excess of AA with excellent reproducibility. The practical utility of the electrode is demonstrated by measuring the concentration of UA in human serum.

収録刊行物

  • The Analyst

    The Analyst 127 (9), 1155-1158, 2002-08-13

    Royal Society of Chemistry (RSC)

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