Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

  • Paul A. Gray
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Hui Fu
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Ping Luo
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Qing Zhao
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Jing Yu
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Annette Ferrari
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Toyoaki Tenzen
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Dong-in Yuk
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Eric F. Tsung
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Zhaohui Cai
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • John A. Alberta
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Le-ping Cheng
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Yang Liu
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Jan M. Stenman
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • M. Todd Valerius
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Nathan Billings
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Haesun A. Kim
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Michael E. Greenberg
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Andrew P. McMahon
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • David H. Rowitch
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Charles D. Stiles
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Qiufu Ma
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

書誌事項

公開日
2004-12-24
DOI
  • 10.1126/science.1104935
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.</jats:p>

収録刊行物

  • Science

    Science 306 (5705), 2255-2257, 2004-12-24

    American Association for the Advancement of Science (AAAS)

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