RNA <i>N</i><sup>6</sup>-methyladenosine methylation in post-transcriptional gene expression regulation

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<jats:p><jats:italic>N</jats:italic><jats:sup>6</jats:sup>-methyladenosine (m<jats:sup>6</jats:sup>A) is the most prevalent and internal modification that occurs in the messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a mystery for decades. This modification is installed by the m<jats:sup>6</jats:sup>A methylation “writers” and can be reversed by demethylases that serve as “erasers.” In this review, we mainly summarize recent progress in the study of the m<jats:sup>6</jats:sup>A mRNA methylation machineries across eukaryotes and discuss their newly uncovered biological functions. The broad roles of m<jats:sup>6</jats:sup>A in regulating cell fates and embryonic development highlight the existence of another layer of epigenetic regulation at the RNA level, where mRNA is subjected to chemical modifications that affect protein expression.</jats:p>

Journal

  • Genes & Development

    Genes & Development 29 (13), 1343-1355, 2015-07-01

    Cold Spring Harbor Laboratory

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