Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

DOI Web Site 7 Citations
  • Yaacov Barak
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...
  • Debbie Liao
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...
  • Weimin He
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...
  • Estelita S. Ong
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...
  • Michael C. Nelson
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...
  • Jerrold M. Olefsky
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...
  • Richard Boland
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...
  • Ronald M. Evans
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037; Department of Medicine, University of California, La Jolla, CA 92093; Division of Endocrinology and Metabolism, San Diego Veterans Affairs Medical Center, La Jolla, CA 92093; The Whittier Diabetes Institute, La Jolla, CA 92093; Department of Medicine and Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA 92093; and Veterans...

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<jats:p> Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor δ (PPAR <jats:italic>δ</jats:italic> ) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving <jats:italic>PPARδ</jats:italic> <jats:sup>−/−</jats:sup> mice exhibit a striking reduction in adiposity relative to wild-type levels. This effect is not reproduced in mice harboring an adipose tissue-specific deletion of PPAR <jats:italic>δ</jats:italic> , and thus likely reflects peripheral PPARδ functions in systemic lipid metabolism. Finally, we observe that PPAR <jats:italic>δ</jats:italic> is dispensable for polyp formation in the intestine and colon of <jats:italic>APC</jats:italic> <jats:sup>min</jats:sup> mice, inconsistent with its recently proposed role in the establishment of colorectal tumors. Together, these observations reveal specific roles for PPAR <jats:italic>δ</jats:italic> in embryo development and adipocyte physiology, but not cancer. </jats:p>

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