-
- Andrew Muroyama
- Departments of Dermatology and Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
-
- Terry Lechler
- Departments of Dermatology and Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
説明
<jats:p>Over the past several decades, numerous studies have greatly expanded our knowledge about how microtubule organization and dynamics are controlled in cultured cells in vitro. However, our understanding of microtubule dynamics and functions in vivo, in differentiated cells and tissues, remains under-explored. Recent advances in generating genetic tools and imaging technologies to probe microtubules in situ, coupled with an increased interest in the functions of this cytoskeletal network in differentiated cells, are resulting in a renaissance. Here, we discuss the lessons learned from such approaches, which have revealed that, although some differentiated cells utilize conserved strategies to remodel microtubules, there is considerable diversity in the underlying molecular mechanisms of microtubule reorganization. This highlights a continued need to explore how differentiated cells regulate microtubule geometry in vivo.</jats:p>
収録刊行物
-
- Development
-
Development 144 (17), 3012-3021, 2017-09-01
The Company of Biologists
