Multidrug evolutionary strategies to reverse antibiotic resistance

DOI Web Site 4 Citations
  • Michael Baym
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Laura K. Stone
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Roy Kishony
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

Description

<jats:title>Evolving antibiotic rescue stratagems</jats:title> <jats:p> Antibiotic resistance threatens to put modern medicine into reverse. But we are not at the end of our options for currently available drugs. Baym <jats:italic>et al.</jats:italic> review what can be done by using combinations of antibiotics to circumvent bacteria's evolutionary strategies. For instance, resistance to one drug may cause sensitivity to another, the effectiveness of two drugs can be synergized by a resistance mutation, and some negative drug interactions may even be beneficial in selecting against resistance. Although not simple to assess, drug combinations still have something to offer for the development of sorely needed anti-infectives. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad3292">10.1126/science.aad3292</jats:related-article> </jats:p>

Journal

  • Science

    Science 351 (6268), aad3292-, 2016-01

    American Association for the Advancement of Science (AAAS)

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