Evidence for rapid disappearance of initially expanded HIV-specific CD8<sup>+</sup>T cell clones during primary HIV infection
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- Giuseppe Pantaleo
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- Hugo Soudeyns
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- James F. Demarest
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- Mauro Vaccarezza
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- Cecilia Graziosi
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- Stefania Paolucci
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- MaryBeth Daucher
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- Oren J. Cohen
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- François Denis
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- William E. Biddison
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- Rafick P. Sekaly
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
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- Anthony S. Fauci
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
Abstract
<jats:p>Down-regulation of the initial burst of viremia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analyzed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance or clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.</jats:p>
Journal
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 94 (18), 9848-9853, 1997-09-02
Proceedings of the National Academy of Sciences
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Details 詳細情報について
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- CRID
- 1360292618994351872
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- ISSN
- 10916490
- 00278424
- http://id.crossref.org/issn/00278424
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- Data Source
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- Crossref