Comparison of pharmacokinetics of L-carnitine, Acetyl-L-carnitine and Propionyl-Lcarnitine after single oral administration of L-carnitine in healthy volunteers

  • Yu Cao
    The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
  • Yun-xiao Wang
    The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
  • Cheng-juan Liu
    The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
  • Le-xin Wang
    School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, Australia.
  • Zhi-wu Han
    The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
  • Chun-bo Wang
    Department of Pharmacology, Medical College, Qingdao University, Qingdao, China

説明

<jats:sec><jats:title>Purpose</jats:title><jats:p> To investigate the pharmacokinetics of L-carnitine (LC) and its analogues, acetyl-L-carnitine (ALC) and propionyl -L-carnitine (PLC) in healthy volunteers after single L-carnitine administration. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects. Plasma and urine concentrations of L-carnitine, ALC and PLC were detected by HPLC. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> The maximum plasma concentration (Cmax) and area under the curve (AUC0-∞) of L-carnitine was 84.7±25.2 μmol˙L-1˙h and 2676.4±708.3 μmol˙L-1˙h, respectively. The elimination half-life of L-carnitine and the time required to reach the Cmax (Tmax) was 60.3±15.0 and 3.4±0.46 h, respectively. The Cmax of ALC (12.9±5.5 μmol˙L-1) and PLC (5.08±3.08 μmol˙L-1) was lower than L-carnitine (P < 0.01), so as the AUC0-− (166.2±77.4 and 155.6±264.2μmol˙L-1˙h, respectively, P < 0.01). The half-life of ALC (35.9±28.9h) and PLC (25.7±30.3 h) was also shorter than L-carnitine (P < 0.01). The 24h accumulated urinary excretion of L-carnitine, ALC and PLC were 613.5±161.7, 368.3±134.8 and 61.3±37.8μmol, respectively. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> L-carnitine has a greater maximum plasma concentration than ALC and PLC. L-carnitine also has a longer half-life than ALC and PLC. These data may have important implications in the designing of dosing regimens for L-carnitine or its analogues, such as ALC or PLC. </jats:p></jats:sec>

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