Genome sequencing and analysis of Aspergillus oryzae
書誌事項
- 公開日
- 2005-12
- 資源種別
- journal article
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1038/nature04300
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and the development of a transformation system have facilitated the use of A. oryzae in modern biotechnology. Although both A. oryzae and Aspergillus flavus belong to the section Flavi of the subgenus Circumdati of Aspergillus, A. oryzae, unlike A. flavus, does not produce aflatoxin, and its long history of use in the food industry has proved its safety. Here we show that the 37-megabase (Mb) genome of A. oryzae contains 12,074 genes and is expanded by 7-9 Mb in comparison with the genomes of Aspergillus nidulans and Aspergillus fumigatus. Comparison of the three aspergilli species revealed the presence of syntenic blocks and A. oryzae-specific blocks (lacking synteny with A. nidulans and A. fumigatus) in a mosaic manner throughout the genome of A. oryzae. The blocks of A. oryzae-specific sequence are enriched for genes involved in metabolism, particularly those for the synthesis of secondary metabolites. Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation.
収録刊行物
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- Nature
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Nature 438 (7071), 1157-1161, 2005-12
Springer Science and Business Media LLC
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キーワード
- genetics: Genes, Fungal
- Genes, Fungal [genetics]
- Molecular Sequence Data
- enzymology: Aspergillus oryzae
- Aspartic Endopeptidases [genetics]
- Genomics
- Synteny
- genetics: Aspartic Endopeptidases
- Cytochrome P-450 Enzyme System [genetics]
- genetics: Chromosomes, Fungal
- Chromosomes, Fungal [genetics]
- Genome, Fungal
- Aspergillus oryzae [enzymology]
- genetics: Cytochrome P-450 Enzyme System
- Phylogeny
詳細情報 詳細情報について
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- CRID
- 1360292619085614592
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- NII論文ID
- 80017738090
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- ISSN
- 14764687
- 00280836
- http://id.crossref.org/issn/00280836
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- 資料種別
- journal article
-
- データソース種別
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- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
