Hemodynamic Characterization of Patients with Severe Emphysema

DOI PDF 被引用文献4件
  • Steven M. Scharf
    Pulmonary and Critical Care Divisions, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York; St. Louis University School of Medicine, St. Louis, Missouri; Temple University School of Medicine, Philadelphia, Pennsylvania; and Johns Hopkins Medical Institutions, Baltimore, Maryland
  • Mobeen Iqbal
    Pulmonary and Critical Care Divisions, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York; St. Louis University School of Medicine, St. Louis, Missouri; Temple University School of Medicine, Philadelphia, Pennsylvania; and Johns Hopkins Medical Institutions, Baltimore, Maryland
  • Cesar Keller
    Pulmonary and Critical Care Divisions, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York; St. Louis University School of Medicine, St. Louis, Missouri; Temple University School of Medicine, Philadelphia, Pennsylvania; and Johns Hopkins Medical Institutions, Baltimore, Maryland
  • Gerald Criner
    Pulmonary and Critical Care Divisions, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York; St. Louis University School of Medicine, St. Louis, Missouri; Temple University School of Medicine, Philadelphia, Pennsylvania; and Johns Hopkins Medical Institutions, Baltimore, Maryland
  • Shing Lee
    Pulmonary and Critical Care Divisions, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York; St. Louis University School of Medicine, St. Louis, Missouri; Temple University School of Medicine, Philadelphia, Pennsylvania; and Johns Hopkins Medical Institutions, Baltimore, Maryland
  • Henry E. Fessler
    Pulmonary and Critical Care Divisions, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York; St. Louis University School of Medicine, St. Louis, Missouri; Temple University School of Medicine, Philadelphia, Pennsylvania; and Johns Hopkins Medical Institutions, Baltimore, Maryland

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公開日
2002-08-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.1164/rccm.2107027
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>In 120 patients with severe emphysema evaluated for participation in the National Emphysema Treatment Trial, pulmonary hemodynamics and ventricular function were assessed. Pulmonary function tests were (%predicted): FEV1 = 27%; residual volume = 224.6%; diffusion capacity = 26.7%. In 90.8% of patients, end-expiratory pulmonary artery mean pressure was &gt; 20 mm Hg; in 61.4%, end-expiratory wedge pressure was &gt; 12 mm Hg. Cardiac index was normal. Mean pulmonary artery pressure correlated inversely with arterial Po2, and severity of emphysema, and directly with wedge pressure. Multiple stepwise regression revealed that arterial Po2 was not an independent predictor of mean pulmonary artery pressure. No correlation was found between indices of emphysema severity and PA pressures. Diastolic ventricular pressures were increased without evidence of systolic dysfunction. We conclude that (1) elevations of pulmonary vascular pressures are common, (2) pulmonary hypertension may be related to factors other than hypoxia, (3) pulmonary hypertension does not impair resting systemic O2 delivery, and (4) elevated cardiac diastolic pressures do not represent systolic dysfunction.</jats:p>

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