Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin

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  • Melissa C. Hendershott
    Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, CA 94158
  • Ronald D. Vale
    Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, CA 94158

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<jats:title>Significance</jats:title> <jats:p> Many microtubule (MT) plus-end regulators have been described, but regulation of MT minus-ends remains poorly understood. Recently, the related calmodulin-regulated spectrin-associated proteins (CAMSAPs) CAMSAP2/3 (vertebrate) and Patronin ( <jats:italic>Drosophila</jats:italic> ) were shown to bind minus-ends, but their effects on MT dynamics in vitro have not been studied. Here, by using in vitro assays, we show that minus-end binding and stabilization are properties of all CAMSAPs. However, their effects on minus-end growth and decoration are variable among different members of this family. Together, these studies solidify the role of CAMSAPs/Patronin as MT minus-end regulatory proteins and reveal how evolution has tuned their activities to affect minus-ends in distinct ways. </jats:p>

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