Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

DOI PDF 16 Citations
  • John R. Teijaro
    *Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201;
  • Damian Turner
    †Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032;
  • Quynh Pham
    ‡Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington CT 06030; and
  • E. John Wherry
    §Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
  • Leo Lefrançois
    ‡Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington CT 06030; and
  • Donna L. Farber
    *Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201;

Description

<jats:title>Abstract</jats:title> <jats:p>We identify in this article a new class of lung tissue-resident memory CD4 T cells that exhibit tissue tropism and retention independent of Ag or inflammation. Tissue-resident memory CD4 T cells in the lung did not circulate or emigrate from the lung in parabiosis experiments, were protected from in vivo Ab labeling, and expressed elevated levels of CD69 and CD11a compared with those of circulating memory populations. Importantly, influenza-specific lung-resident memory CD4 T cells served as in situ protectors to respiratory viral challenge, mediating enhanced viral clearance and survival to lethal influenza infection. By contrast, memory CD4 T cells isolated from spleen recirculated among multiple tissues without retention and failed to mediate protection to influenza infection, despite their ability to expand and migrate to the lung. Our results reveal tissue compartmentalization as a major determining factor for immune-mediated protection in a key mucosal site, important for targeting local protective responses in vaccines and immunotherapies.</jats:p>

Journal

  • The Journal of Immunology

    The Journal of Immunology 187 (11), 5510-5514, 2011-12-01

    The American Association of Immunologists

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