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- M. Fishelson
- Computer Science Department, Technion, Haifa 32000, Israel
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- D. Geiger
- Computer Science Department, Technion, Haifa 32000, Israel
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Motivation: Genetic linkage analysis is a useful statistical tool for mapping disease genes and for associating functionality of genes with their location on the chromosome. There is a need for a program that computes multipoint likelihood on general pedigrees with many markers that also deals with two-locus disease models.</jats:p> <jats:p>Results: In this paper we present algorithms for performing exact multipoint likelihood calculations on general pedigrees with a large number of highly polymorphic markers, taking into account a variety of disease models. We have implemented these algorithms in a new computer program called superlink which outperforms leading linkage software with regards to functionality, speed, memory requirements and extensibility.</jats:p> <jats:p>Availability: superlink is available at http://bioinfo.cs.technion.ac.il/superlink</jats:p> <jats:p>Contact: fmaayan@cs.technion.ac.ildang@cs.technion.ac.il</jats:p> <jats:p>Keywords: Bayesian networks; Fastlink; Genehunter; linkage analysis; Vitesse.</jats:p>
収録刊行物
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- Bioinformatics
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Bioinformatics 18 (suppl_1), S189-S198, 2002-07-01
Oxford University Press (OUP)