Elevated Blood Ammonia Level Is a Potential Biological Risk Factor of Behavioral Disorders in Prisoners
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- Yunfeng Duan
- Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16, Lincui Road, Chaoyang District, Beijing 100101, China
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- Xiaoli Wu
- Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16, Lincui Road, Chaoyang District, Beijing 100101, China
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- Shan Liang
- Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16, Lincui Road, Chaoyang District, Beijing 100101, China
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- Feng Jin
- Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16, Lincui Road, Chaoyang District, Beijing 100101, China
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説明
<jats:p>Hydrothion (H<jats:sub>2</jats:sub>S) and ammonia (NH<jats:sub>3</jats:sub>) can be toxic for the human central nervous system and cause psychological disturbances and behavioral disorders. In order to evaluate the association between the two potential toxicants and mental health, in this study, we compare a male prisoner and control population. Forty-nine male prisoners and 52 control volunteers took part in the study. An aggressive behavior assessment, the Self-Rating Depression Scale (SDS), and the State-Trait Anxiety Inventory (STAI) were used to characterize the participants’ mental health status. Venous blood was collected for detection of H<jats:sub>2</jats:sub>S and NH<jats:sub>3</jats:sub>. The results indicated that blood NH<jats:sub>3</jats:sub>was significantly higher in male prisoners than in controls. However, blood H<jats:sub>2</jats:sub>S was significantly lower. Blood NH<jats:sub>3</jats:sub>was also significantly and positively correlated with prisoners. In the multivariate adjusted models, after controlling for age, education, marital status, and BMI, we found a positive association between NH<jats:sub>3</jats:sub>and prisoners, but not blood H<jats:sub>2</jats:sub>S. While the functions of the two toxicants were quite different, blood NH<jats:sub>3</jats:sub>may be a potential biological risk factor for behavioral disorders and blood H<jats:sub>2</jats:sub>S showed neuroprotection. Additionally, the impact of other factors such as diet and gut bacteria should be considered when evaluating risk for behavioral disorders.</jats:p>
収録刊行物
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- Behavioural Neurology
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Behavioural Neurology 2015 1-5, 2015
Wiley