Iron Overload Augments Angiotensin II–Induced Cardiac Fibrosis and Promotes Neointima Formation

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  • Nobukazu Ishizaka
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Kan Saito
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Haruo Mitani
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Ieharu Yamazaki
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Masataka Sata
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Shin-ichi Usui
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Ichiro Mori
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Minoru Ohno
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).
  • Ryozo Nagai
    From the Department of Cardiovascular Medicine (N.I., K.S., H.M., M.S., S.U., M.O., R.N.), University of Tokyo Graduate School of Medicine; the Department of Pathology, Wakayama (Japan) Medical College (I.M.); and the Department of Pathology, Inoue (Japan) Memorial Hospital (I.Y.).

説明

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> Abnormal iron deposition may cause oxidant-induced damage in various organs. We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II–induced renal damage. In the present study, we investigated the role of iron in the development of cardiac injury induced by angiotensin II. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> Angiotensin II was continuously infused to rats at a dose of 0.7 mg/kg per day for 7 consecutive days. No iron deposits were observed in the hearts of untreated rats, whereas iron deposition was seen in the cells in the subepicardial and granulation regions after angiotensin II infusion. Concomitant administration of deferoxamine, an iron chelator, significantly reduced the extent of cardiac fibrosis, which suggests that iron deposition aggravates the cardiac fibrosis induced by angiotensin II. Iron overload caused by the administration of iron-dextran resulted in an augmentation of cardiac fibrosis and the generation of neointimal cells in the coronary artery in angiotensin II–infused rats. By contrast, neointima was not formed in the cardiac vessels in norepinephrine-infused rats with iron overload. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> Cardiac iron deposition may be involved in the development of cardiac fibrosis induced by angiotensin II. In addition, iron overload may enhance the formation of neointima under conditions of increased circulating angiotensin II but not catecholamines. </jats:p>

収録刊行物

  • Circulation

    Circulation 106 (14), 1840-1846, 2002-10

    Ovid Technologies (Wolters Kluwer Health)

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