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- Shuichi Hoshika
- Firebird Biomolecular Sciences LLC, 13709 Progress Boulevard, No. 17, Alachua, FL 32615, USA.
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- Nicole A. Leal
- Firebird Biomolecular Sciences LLC, 13709 Progress Boulevard, No. 17, Alachua, FL 32615, USA.
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- Myong-Jung Kim
- Firebird Biomolecular Sciences LLC, 13709 Progress Boulevard, No. 17, Alachua, FL 32615, USA.
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- Myong-Sang Kim
- Firebird Biomolecular Sciences LLC, 13709 Progress Boulevard, No. 17, Alachua, FL 32615, USA.
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- Nilesh B. Karalkar
- Firebird Biomolecular Sciences LLC, 13709 Progress Boulevard, No. 17, Alachua, FL 32615, USA.
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- Hyo-Joong Kim
- Firebird Biomolecular Sciences LLC, 13709 Progress Boulevard, No. 17, Alachua, FL 32615, USA.
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- Alison M. Bates
- Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
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- Norman E. Watkins
- DNA Software Inc., Ann Arbor, MI 48104, USA.
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- Holly A. SantaLucia
- DNA Software Inc., Ann Arbor, MI 48104, USA.
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- Adam J. Meyer
- Center for Systems and Synthetic Biology, University of Texas, Austin, TX 78703, USA.
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- Saurja DasGupta
- Department of Biochemistry and Molecular Biology and Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
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- Joseph A. Piccirilli
- Department of Biochemistry and Molecular Biology and Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
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- Andrew D. Ellington
- Center for Systems and Synthetic Biology, University of Texas, Austin, TX 78703, USA.
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- John SantaLucia
- DNA Software Inc., Ann Arbor, MI 48104, USA.
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- Millie M. Georgiadis
- Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
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- Steven A. Benner
- Firebird Biomolecular Sciences LLC, 13709 Progress Boulevard, No. 17, Alachua, FL 32615, USA.
説明
<jats:title>Expanding the genetic code</jats:title> <jats:p> DNA and RNA are naturally composed of four nucleotide bases that form hydrogen bonds in order to pair. Hoshika <jats:italic>et al.</jats:italic> added an additional four synthetic nucleotides to produce an eight-letter genetic code and generate so-called hachimoji DNA. Coupled with an engineered T7 RNA polymerase, this expanded DNA alphabet could be transcribed into RNA. Thus, new forms of DNA that add information density to genetic biopolymers can be generated that may be useful for future synthetic biological applications. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6429" page="884" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aat0971">884</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 363 (6429), 884-887, 2019-02-22
American Association for the Advancement of Science (AAAS)
