Combined Surgery and Radiation Therapy for Squamous Cell Carcinoma of the Hypopharynx

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  • Dennis H. Kraus
    Head and Neck Service Department of Surgery Memorial Sloan‐Kettering Cancer Center New York New York
  • Michael J. Zelefsky
    Brachytherapy Service Department of Radiation Therapy Memorial Sloan‐Kettering Cancer Center New York New York
  • Heidi A. J. Brock
    Head and Neck Service Department of Surgery Memorial Sloan‐Kettering Cancer Center New York New York
  • Jerry Huo
    Head and Neck Service Department of Surgery Memorial Sloan‐Kettering Cancer Center New York New York
  • Louis B. Harrison
    Brachytherapy Service Department of Radiation Therapy Memorial Sloan‐Kettering Cancer Center New York New York
  • Jatin P Shah
    Head and Neck Service Department of Surgery Memorial Sloan‐Kettering Cancer Center New York New York

説明

<jats:p>Squamous cell carcinoma of the hypopharynx remains a highly lethal disease. This article documents our experience with 132 patients undergoing surgical management of squamous cell carcinoma of the hypopharynx, of whom 80% received postoperative radiation therapy. Local‐regional control was obtained in 61% of the patients. Five‐year overall and disease‐free survival rates were 30% and 41%, respectively. Prognosis was better in patients with limited disease: local disease permitting larynx‐sparing surgery, N0/N1 clinical neck, and stage I/II/III disease. Cancer of the hypopharynx remains an aggressive entity associated with poor prognosis. Novel strategies stressing improved local‐regional control with prevention of distant metastasis are warranted.</jats:p>

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