Dietary Curcumin: Correlation between Bioavailability and Health Potential
-
- Michele Dei Cas
- Department of Health Sciences, Università degli Studi di Milano, 20142 Milan, Italy
-
- Riccardo Ghidoni
- Department of Health Sciences, Università degli Studi di Milano, 20142 Milan, Italy
Description
<jats:p>The yellow pigment curcumin, extracted from turmeric, is a renowned polyphenol with a broad spectrum of health properties such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, hepatoprotective, anti-allergic, anti-dermatophyte, and neuroprotective. However, these properties are followed by a poor pharmacokinetic profile which compromises its therapeutic potential. The association of low absorption by the small intestine and the extensive reductive and conjugative metabolism in the liver dramatically weakens the oral bioavailability. Several strategies such as inhibition of curcumin metabolism with adjuvants as well as novel solid and liquid oral delivery systems have been tried to counteract curcumin poor absorption and rapid elimination from the body. Some of these drug deliveries can successfully enhance the solubility, extending the residence in plasma, improving the pharmacokinetic profile and the cellular uptake.</jats:p>
Journal
-
- Nutrients
-
Nutrients 11 (9), 2147-, 2019-09-08
MDPI AG
- Tweet
Details 詳細情報について
-
- CRID
- 1360292619701062528
-
- ISSN
- 20726643
-
- Data Source
-
- Crossref