Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection
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- John R. Teijaro
- Department of Immunology and Microbial Science,
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- Kevin B. Walsh
- Department of Immunology and Microbial Science,
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- Stephanie Rice
- Department of Immunology and Microbial Science,
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- Hugh Rosen
- Department of Chemical Physiology, Skaggs Institute for Chemical Biology, and
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- Michael B. A. Oldstone
- Department of Immunology and Microbial Science,
抄録
<jats:title>Significance</jats:title> <jats:p> Cytokine storm plays an essential and commanding role in the clinical outcome and pathogenesis of influenza virus infection. We previously documented that a small molecule that activates sphingosine-1-phosphate-1 receptor (S1P <jats:sub>1</jats:sub> R) signaling is primarily responsible for blunting cytokine storm to protect the infected host from the consequences of influenza infection. In the present study, we map host innate signaling pathways of cytokine storm and chart where along those pathways the drug is effective. We find that the efficacy of S1P <jats:sub>1</jats:sub> R agonist in blunting cytokine storm is through global inhibition downstream of myeloid differentiation primary response gene 88 and IFN-β promoter stimulator-1 signaling. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 111 (10), 3799-3804, 2014-02-26
Proceedings of the National Academy of Sciences