Cerebral perfusion assessment by bolus tracking using hyperpolarized <sup>13</sup>C

DOI Web Site Web Site 被引用文献4件

説明

<jats:title>Abstract</jats:title><jats:p>Cerebral perfusion was assessed with <jats:sup>13</jats:sup>C MRI in a rat model after intravenous injections of the <jats:sup>13</jats:sup>C‐labeled compound <jats:italic>bis</jats:italic>‐1,1‐(hydroxymethyl)‐1‐<jats:sup>13</jats:sup>C‐cyclopropane‐D<jats:sub>8</jats:sub> in aqueous solutions hyperpolarized by dynamic nuclear polarization (DNP). Since the tracer acted as a direct signal source, several of the problems associated with techniques based on traditional dynamic susceptibility contrast (DSC) MRI contrast agents were avoided. Maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were calculated. The MTT was determined to be 2.8 ± 0.8 sec. However, arterial partial‐volume effects in the animal model prevented accurate absolute quantification of CBF and CBV. It was demonstrated that depolarization of the hyperpolarized <jats:sup>13</jats:sup>C tracer via relaxation and the imaging sequence had little influence on CBF assessment when the time resolution of the imaging sequence was short compared to the MTT. However, CBV and MTT were increasingly underestimated as MTT or the depolarization rate increased if depolarization was not taken into account. With a modified bolus‐tracking theory depolarization could be compensated for, assuming that the depolarization rate was known. Three separate compensation methods were investigated experimentally and by numerical simulations. Magn Reson Med 51:464–472, 2004. © 2004 Wiley‐Liss, Inc.</jats:p>

収録刊行物

被引用文献 (4)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ