Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

RJ Keizer, MO Karlsson, A Hooker

doi:10.1038/psp.2013.24

Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

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RJ Keizer

Department of Pharmaceutical Biosciences Pharmacometrics research Group, Uppsala University Uppsala Sweden
MO Karlsson

Department of Pharmaceutical Biosciences Pharmacometrics research Group, Uppsala University Uppsala Sweden
A Hooker

Department of Pharmaceutical Biosciences Pharmacometrics research Group, Uppsala University Uppsala Sweden

書誌事項

公開日: 2013-06

権利情報

http://creativecommons.org/licenses/by-nc-nd/3.0/

DOI

10.1038/psp.2013.24

公開者: Wiley

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説明

<jats:p>Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integrated workbench for modeling and simulation with NONMEM. During the tutorial, we provide some guidance on what diagnostics we consider most useful in pharmacokinetic model development and how to construct them using these tools.</jats:p><jats:p><jats:italic>CPT: Pharmacometrics & Systems Pharmacology</jats:italic> (2013) 2, e50; doi:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" xlink:href="10.1038/psp.2013.24">10.1038/psp.2013.24</jats:ext-link>; advance online publication 26 June 2013</jats:p>