Solid Cancers After Bone Marrow Transplantation
-
- Smita Bhatia
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Andrew D. Louie
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Ravi Bhatia
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Margaret R. O’Donnell
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Henry Fung
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Ashwin Kashyap
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Amrita Krishnan
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Arturo Molina
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Auayporn Nademanee
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Joyce C. Niland
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Pablo A. Parker
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- David S. Snyder
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Ricardo Spielberger
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Anthony Stein
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
-
- Stephen J. Forman
- From the Divisions of Hematology and Bone Marrow Transplantation, Pediatric Oncology, Biostatistics, and Pathology, City of Hope National Medical Center, Duarte, CA.
Abstract
<jats:p> PURPOSE: To evaluate the incidence and associated risk factors of solid cancers after bone marrow transplantation (BMT). </jats:p><jats:p> PATIENTS AND METHODS: We analyzed 2,129 patients who had undergone BMT for hematologic malignancies at the City of Hope National Medical Center between 1976 and 1998. A retrospective cohort and nested case-control study design were used to evaluate the role of pretransplantation therapeutic exposures and transplant conditioning regimens. </jats:p><jats:p> RESULTS: Twenty-nine patients developed solid cancers after BMT, which represents a two-fold increase in risk compared with a comparable normal population. The estimated cumulative probability (± SE) for development of a solid cancer was 6.1% ± 1.6% at 10 years. The risk was significantly elevated for liver cancer (standardized incidence ratio [SIR], 27.7; 95% confidence interval [CI], 1.9 to 57.3), cancer of the oral cavity (SIR, 17.4; 95% CI, 6.3 to 34.1), and cervical cancer (SIR, 13.3; 95% CI, 3.5 to 29.6). Each of the two patients with liver cancer had a history of chronic hepatitis C infection. All six patients with squamous cell carcinoma of the skin had chronic graft-versus-host disease. The risk was significantly higher for survivors who were younger than 34 years of age at time of BMT (SIR, 5.3; 95% CI, 2.7 to 8.6). Cancers of the thyroid gland, liver, and oral cavity occurred primarily among patients who received total-body irradiation. </jats:p><jats:p> CONCLUSION: The risk of radiation-associated solid tumor development after BMT is likely to increase with longer follow-up. This underscores the importance of close monitoring of patients who undergo BMT. </jats:p>
Journal
-
- Journal of Clinical Oncology
-
Journal of Clinical Oncology 19 (2), 464-471, 2001-01-15
American Society of Clinical Oncology (ASCO)
- Tweet
Details 詳細情報について
-
- CRID
- 1360292619852033280
-
- ISSN
- 15277755
- 0732183X
- http://id.crossref.org/issn/0732183X
-
- Data Source
-
- Crossref