Enantioselective Friedel–Crafts reaction of indoles with trifluoroacetaldehyde catalyzed by Cinchona alkaloids
書誌事項
- 公開日
- 2011-07-11
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/chir.20982
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The first direct asymmetric synthetic preparation of trifluoro‐1‐(indol‐3‐yl)ethanols (TFIEs) is described by an enantioselective organocatalytic method from indoles and inexpensive trifluoroacetaldehyde methyl hemiacetal. The reaction is catalyzed by hydroquinine to produce TFIEs in an almost quantitative yield and with enantioselectivities up to 75% at room temperature. The enantioselectivity is strongly dependent on the concentration of substrates and catalyst due to the competitive noncatalyzed reaction. Chirality, 2011. © 2011 Wiley‐Liss, Inc.</jats:p>
収録刊行物
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- Chirality
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Chirality 23 (8), 612-616, 2011-07-11
Wiley