Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

DOI Web Site 4 Citations
  • Reena Lasrado
    The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Werend Boesmans
    The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Jens Kleinjung
    The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Carmen Pin
    Institute of Food Research, Norwich NR4 7UA, UK.
  • Donald Bell
    The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Leena Bhaw
    The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Sarah McCallum
    The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Hui Zong
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Liqun Luo
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Hans Clevers
    Hubrecht Institute–KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Centre Utrecht, 3584 CT Utrecht, Netherlands.
  • Pieter Vanden Berghe
    Laboratory for Enteric Neuroscience (LENS), Translational Research in GastroIntestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium.
  • Vassilis Pachnis
    The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Description

<jats:title>Neural crest rules the gut</jats:title> <jats:p> The neurons and glial cells that regulate gut function derive from neural crest cells that emerge from the developing neural tube. Lasrado <jats:italic>et al.</jats:italic> used single-cell transcriptomics and mosaic mutagenesis to follow how the enteric nervous system is built in mice. Overlapping expression of regulatory programs supports dynamic determination of cell fates, with the developing neurons organized by clonal lineages. The clonal build model may explain how gut motility is coordinated in sequential segments and gut secretion is coordinated with motility. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6339" page="722" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aam7511">722</jats:related-article> </jats:p>

Journal

  • Science

    Science 356 (6339), 722-726, 2017-05-19

    American Association for the Advancement of Science (AAAS)

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