Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing<i>bam</i>transcription in the<i>Drosophila</i>testis

DOI PDF 被引用文献3件
  • Eihachiro Kawase
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
  • Marco D. Wong
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
  • Bee C. Ding
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
  • Ting Xie
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA

書誌事項

公開日
2004-03-15
DOI
  • 10.1242/dev.01025
公開者
The Company of Biologists

この論文をさがす

説明

<jats:p>Stem cells are responsible for replacing damaged or dying cells in various adult tissues throughout a lifetime. They possess great potential for future regenerative medicine and gene therapy. However, the mechanisms governing stem cell regulation are poorly understood. Germline stem cells (GSCs) in the Drosophila testis have been shown to reside in niches, and thus these represent an excellent system for studying relationships between niches and stem cells. Here we show that Bmp signals from somatic cells are essential for maintaining GSCs in the Drosophila testis. Somatic cyst cells and hub cells express two Bmp molecules, Gbb and Dpp. Our genetic analysis indicates that gbb functions cooperatively with dpp to maintain male GSCs, although gbb alone is essential for GSC maintenance. Furthermore, mutant clonal analysis shows that Bmp signals directly act on GSCs and control their maintenance. In GSCs defective in Bmp signaling,expression of bam is upregulated, whereas forced bamexpression in GSCs causes the GSCs to be lost. This study demonstrates that Bmp signals from the somatic cells maintain GSCs, at least in part, by repressing bam expression in the Drosophila testis. dpp signaling is known to be essential for maintaining GSCs in the Drosophila ovary. This study further suggests that both Drosophila male and female GSCs use Bmp signals to maintain GSCs.</jats:p>

収録刊行物

  • Development

    Development 131 (6), 1365-1375, 2004-03-15

    The Company of Biologists

被引用文献 (3)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ