Scavenging of reactive oxygen species by novel indolin‐2‐one and indoline‐2‐thione derivatives
書誌事項
- 公開日
- 2005-03-09
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/bip.20268
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The antioxidant behavior of a series of new synthesized substituted indoline‐2‐ones and indolin‐2‐thiones was investigated in this study using an oxygen radical absorbance capacity assay (ORAC<jats:styled-content>$_{ROO\mathop{\bullet}^{\!\!\!\!-}}$<jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/tex2gif-ueqn-1.gif" xlink:title="equation image" /></jats:styled-content>) and 2,2′‐azobis(2‐amidino‐propane) dihydrochloride (AAPH) as the radical generator; system generating superoxide anion radical, <jats:styled-content>$O^{{\mathop{\bullet}^{\!\!\!\!-}}}_2$<jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/tex2gif-ueqn-2.gif" xlink:title="equation image" /></jats:styled-content> (18‐crown‐6/KO<jats:sub>2</jats:sub>/DMSO), and the Fenton‐like reaction [Co(II) + H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> → Co(III) + HO<jats:sup>•</jats:sup> + HO<jats:sup>−</jats:sup>]. Measurements were done using fluorescence, chemiluminescence methods, and a deoxyribose assay based on the spectrophotometry method, respectively. The results obtained indicated that the examined indoline derivatives had effective activities as radical scavengers and may be considered as an effective source for combating oxidative damage. © 2005 Wiley Periodicals, Inc. Biopolymers 78: 171–178, 2005</jats:p>
収録刊行物
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- Biopolymers
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Biopolymers 78 (4), 171-178, 2005-03-09
Wiley
