Comparative Genomics of Trypanosomatid Parasitic Protozoa

DOI Web Site 被引用文献7件
  • Najib M. El-Sayed
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Peter J. Myler
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Gaëlle Blandin
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Matthew Berriman
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jonathan Crabtree
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Gautam Aggarwal
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Elisabet Caler
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Hubert Renauld
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Elizabeth A. Worthey
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Christiane Hertz-Fowler
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Christopher Peacock
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Daniella C. Bartholomeu
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Brian J. Haas
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Anh-Nhi Tran
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jennifer R. Wortman
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • U. Cecilia M. Alsmark
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Samuel Angiuoli
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Atashi Anupama
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jonathan Badger
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Frederic Bringaud
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Eithon Cadag
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jane M. Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Gustavo C. Cerqueira
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Todd Creasy
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Arthur L. Delcher
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Appolinaire Djikeng
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • T. Martin Embley
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Christopher Hauser
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Alasdair C. Ivens
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Sarah K. Kummerfeld
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jose B. Pereira-Leal
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Daniel Nilsson
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jeremy Peterson
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Steven L. Salzberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Joshua Shallom
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Joana C. Silva
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Jaideep Sundaram
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Scott Westenberger
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Owen White
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Sara E. Melville
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • John E. Donelson
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Björn Andersson
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Kenneth D. Stuart
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
  • Neil Hall
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

抄録

<jats:p> A comparison of gene content and genome architecture of <jats:italic>Trypanosoma brucei, Trypanosoma cruzi</jats:italic> , and <jats:italic>Leishmania major</jats:italic> , three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that—along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions—have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont. </jats:p>

収録刊行物

  • Science

    Science 309 (5733), 404-409, 2005-07-15

    American Association for the Advancement of Science (AAAS)

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