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- Taylor R. T. Dagenais
- Medical Microbiology and Immunology, University of Wisconsin—Madison, Madison, Wisconsin
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- Nancy P. Keller
- Medical Microbiology and Immunology, University of Wisconsin—Madison, Madison, Wisconsin
説明
<jats:sec><jats:title>SUMMARY</jats:title><jats:p><jats:italic>Aspergillus</jats:italic>species are globally ubiquitous saprophytes found in a variety of ecological niches. Almost 200 species of aspergilli have been identified, less than 20 of which are known to cause human disease. Among them,<jats:italic>Aspergillus fumigatus</jats:italic>is the most prevalent and is largely responsible for the increased incidence of invasive aspergillosis (IA) in the immunocompromised patient population. IA is a devastating illness, with mortality rates in some patient groups reaching as high as 90%. Studies identifying and assessing the roles of specific factors of<jats:italic>A. fumigatus</jats:italic>that contribute to the pathogenesis of IA have traditionally focused on single-gene deletion and mutant characterization. In combination with recent large-scale approaches analyzing global fungal responses to distinct environmental or host conditions, these studies have identified many factors that contribute to the overall pathogenic potential of<jats:italic>A. fumigatus</jats:italic>. Here, we provide an overview of the significant findings regarding<jats:italic>A. fumigatus</jats:italic>pathogenesis as it pertains to invasive disease.</jats:p></jats:sec>
収録刊行物
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- Clinical Microbiology Reviews
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Clinical Microbiology Reviews 22 (3), 447-465, 2009-07
American Society for Microbiology
