説明
The metastasis of malignant tumor cells from the primary tumor to distant sites in the body is a complex process. To identify genes that may be essential for metastasis, we established poorly metastatic mouse melanoma cells, namely Y925F-mutated FAK-transfected cells (Y925F cells), from the highly metastatic mouse melanoma cell line B16F10, and performed expression analyses. The expression of phospholipid protein 2 (PLP2) was markedly down-regulated in the Y925F cells. To elucidate the function of PLP2, we established melanoma cells overexpressing PLP2. We found that PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo. These results suggest that PLP2 aids metastasis. Furthermore, we showed that PLP2 binds specifically to PI3K, thus activating Akt.
収録刊行物
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- Oncology Reports
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Oncology Reports 23 (2), 2009-12-28
Spandidos Publications
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キーワード
- Lung Neoplasms
- Skin Neoplasms
- Proteolipids
- Melanoma, Experimental
- Mice
- Phosphatidylinositol 3-Kinases
- Cell Movement
- Cell Adhesion
- Tumor Cells, Cultured
- Animals
- Neoplasm Metastasis
- Myelin Proteolipid Protein
- MARVEL Domain-Containing Proteins
- Membrane Proteins
- Enzyme Activation
- Gene Expression Regulation, Neoplastic
- Mice, Inbred C57BL
- Oncogene Protein v-akt
- Matrix Metalloproteinase 2
- Rabbits
詳細情報 詳細情報について
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- CRID
- 1360292620604319104
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- ISSN
- 17912431
- 1021335X
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- PubMed
- 20043097
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- データソース種別
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- Crossref
- OpenAIRE
