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- Kyeong-A Ryu
- Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Korea
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- Phil June Park
- Department of Genetic Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do 16499, Korea
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- Seong-Bo Kim
- Bio-Living Engineering Major, Global Leaders College, Yonsei University, 50 yonsei-ro, Shinchon-dong, Seodaemun-gu, Seoul 03722, Korea
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- Bum-Ho Bin
- Department of Biological Sciences, Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea
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- Dong-Jin Jang
- Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Korea
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- Sung Tae Kim
- Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Korea
説明
<jats:p>The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL®, and Transcutol® HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (w/w %) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (w/w %). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL®, and Transcutol® HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin.</jats:p>
収録刊行物
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- Pharmaceutics
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Pharmaceutics 12 (4), 332-, 2020-04-07
MDPI AG