Redundancy and specialization among plant microRNAs: role of the<i>MIR164</i>family in developmental robustness

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  • Patrick Sieber
    Division of Biology, California Institute of Technology, Pasadena, CA 91125,USA.
  • Frank Wellmer
    Division of Biology, California Institute of Technology, Pasadena, CA 91125,USA.
  • Jacqueline Gheyselinck
    Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland.
  • José Luis Riechmann
    Division of Biology, California Institute of Technology, Pasadena, CA 91125,USA.
  • Elliot M. Meyerowitz
    Division of Biology, California Institute of Technology, Pasadena, CA 91125,USA.

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<jats:p>In plants, members of microRNA (miRNA) families are often predicted to target the same or overlapping sets of genes. It has thus been hypothesized that these miRNAs may act in a functionally redundant manner. This hypothesis is tested here by studying the effects of elimination of all three members of the MIR164 family from Arabidopsis. It was found that a loss of miR164 activity leads to a severe disruption of shoot development,in contrast to the effect of mutation in any single MIR164 gene. This indicates that these miRNAs are indeed functionally redundant. Differences in the expression patterns of the individual MIR164 genes imply,however, that redundancy among them is not complete, and that these miRNAs show functional specialization. Furthermore, the results of molecular and genetic analyses of miR164-mediated target regulation indicate that miR164 miRNAs function to control the transcript levels, as well as the expression patterns, of their targets, suggesting that they might contribute to developmental robustness. For two of the miR164targets, namely CUP-SHAPED COTYLEDON1 (CUC1) and CUC2, we provide evidence for their involvement in the regulation of growth and show that their derepression in miR164 loss-of-function mutants is likely to account for most of the mutant phenotype.</jats:p>

収録刊行物

  • Development

    Development 134 (6), 1051-1060, 2007-03-15

    The Company of Biologists

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