Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

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  • Mattia Bonsignori
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Edward F. Kreider
    Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Daniela Fera
    Laboratory of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • R. Ryan Meyerhoff
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Todd Bradley
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Kevin Wiehe
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • S. Munir Alam
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Baptiste Aussedat
    Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • William E. Walkowicz
    Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Kwan-Ki Hwang
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Kevin O. Saunders
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Ruijun Zhang
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Morgan A. Gladden
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Anthony Monroe
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Amit Kumar
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Shi-Mao Xia
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Melissa Cooper
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Mark K. Louder
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Krisha McKee
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Robert T. Bailer
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Brendan W. Pier
    Laboratory of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Claudia A. Jette
    Laboratory of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Garnett Kelsoe
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Wilton B. Williams
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Lynn Morris
    National Institute for Communicable Diseases, Johannesburg 2131, South Africa.
  • John Kappes
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Kshitij Wagh
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  • Gift Kamanga
    University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi.
  • Myron S. Cohen
    Departments of Medicine, Epidemiology, and Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Peter T. Hraber
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  • David C. Montefiori
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Ashley Trama
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Hua-Xin Liao
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Thomas B. Kepler
    Department of Microbiology and Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
  • M. Anthony Moody
    Duke Human Vaccine Institute, Durham, NC 27710, USA.
  • Feng Gao
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Samuel J. Danishefsky
    Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • John R. Mascola
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • George M. Shaw
    Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Beatrice H. Hahn
    Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Stephen C. Harrison
    Laboratory of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Bette T. Korber
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  • Barton F. Haynes
    Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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<jats:p>Identification of maturation stages of V3-glycan neutralizing antibodies explains the long duration required for their development.</jats:p>

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