Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats.
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- D Mukherjee
- Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195-5071.
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- S Sen
- Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195-5071.
Description
<jats:p>The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen phenotypes during the evolution of hypertensive hypertrophy. Therapy with captopril, an angiotensin-converting enzyme inhibitor that regresses cardiac hypertrophy, not only reduces the total amount of collagen but reverses the altered distribution of type I and type III collagen. In normotensive rats, captopril did not significantly reduce collagen content or alter the ratio of type I to type III collagen.</jats:p>
Journal
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- Circulation Research
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Circulation Research 67 (6), 1474-1480, 1990-12
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1360292620920621568
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- ISSN
- 15244571
- 00097330
- http://id.crossref.org/issn/00097330
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- Data Source
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- Crossref