A Novel Cost‐Effective Thiourea Bifunctional Organocatalyst for Highly Enantioselective Alcoholysis of <i>meso</i>‐Cyclic Anhydrides: Enhanced Enantioselectivity by Configuration Inversion

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<jats:title>Abstract</jats:title><jats:p><jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/gif" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/mcontent.gif"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p><jats:p>A novel inexpensive thiourea bifunctional organocatalyst which can promote the highly enantioselective (up to 95% <jats:italic>ee</jats:italic>) alcoholysis of <jats:italic>meso</jats:italic>‐cyclic anhydrides has been developed. Computational studies on the catalytic process as well as a synthetic application of this new catalyst are also presented.</jats:p>

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