Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

DOI Web Site Web Site 2 Citations
  • Vittoria Zoppi
    Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom
  • Scott J. Hughes
    Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom
  • Chiara Maniaci
    Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom
  • Andrea Testa
    Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom
  • Teresa Gmaschitz
    Boehringer Ingelheim RCV GmbH & Co. KG, 1221 Vienna, Austria
  • Corinna Wieshofer
    Boehringer Ingelheim RCV GmbH & Co. KG, 1221 Vienna, Austria
  • Manfred Koegl
    Boehringer Ingelheim RCV GmbH & Co. KG, 1221 Vienna, Austria
  • Kristin M. Riching
    Promega Corporation, 2800 Woods Hollow Road, Madison, Wisconsin 53711, United States
  • Danette L. Daniels
    Promega Corporation, 2800 Woods Hollow Road, Madison, Wisconsin 53711, United States
  • Andrea Spallarossa
    Dipartimento di Farmacia, Sezione di Chimica del Farmaco e del Prodotto Cosmetico, Università degli Studi di Genova, Viale Benedetto XV 3, 16132 Genova, Italy
  • Alessio Ciulli
    Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre, University of Dundee, Dow Street, DD1 5EH, Dundee, Scotland, United Kingdom

Journal

Citations (2)*help

See more

Report a problem

Back to top