Prognostic Value of Minimal Residual Disease Quantification Before Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia: The ALL-REZ BFM Study Group
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- Peter Bader
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Hermann Kreyenberg
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Günter H.R. Henze
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Cornelia Eckert
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Miriam Reising
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Andre Willasch
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Andrea Barth
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Arndt Borkhardt
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Christina Peters
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Rupert Handgretinger
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Karl-Walter Sykora
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Wolfgang Holter
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Hartmut Kabisch
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Thomas Klingebiel
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
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- Arend von Stackelberg
- From the Children's Hospital of the J.W. Goethe University, Frankfurt; Charité, Pediatric Oncology/Hematology, Berlin; University Medical Center, Pediatric Oncology/Hematology, Düsseldorf; University Children's Hospital Tübingen, Tübingen; Medizinische Hochschule Hannover, Hannover; University Children's Hospital, Erlangen, Erlangen; University Children's Hospital Hamburg, Hamburg, Germany; and St Anna Kinderspital, Pediatric Oncology/Hematology, Vienna, Austria
説明
<jats:sec><jats:title>Purpose</jats:title><jats:p> Minimal residual disease (MRD) before allogeneic stem-cell transplantation was shown to predict outcome in children with relapsed acute lymphoblastic leukemia (ALL) in retrospective analysis. To verify this, the Acute Lymphoblastic Leukemia Relapse Berlin-Frankfurt-Münster (ALL-REZ BFM) Study Group conducted a prospective trial. </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Between March 1999 and July 2005, 91 children with relapsed ALL treated according to the ALL-REZ BFM 96 or 2002 protocols and receiving stem-cell transplantation in ≥ second remission were enrolled. MRD quantification was performed by real-time polymerase chain reaction using T-cell receptor and immunoglobulin gene rearrangements. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Probability of event-free survival (pEFS) and cumulative incidence of relapse (CIR) in 45 patients with MRD ≥ 10<jats:sup>−4</jats:sup> leukemic cells was 0.27 and 0.57 compared with 0.60 and 0.13 in 46 patients with MRD less than 10<jats:sup>−4</jats:sup> leukemic cells (EFS, P = .004; CIR, P < .001). Intermediate-risk patients (strategic group S1) with MRD ≥ 10<jats:sup>−4</jats:sup> leukemic cells (n = 14) had a pEFS of 0.20 and CIR of 0.73, whereas patients with MRD less than 10<jats:sup>−4</jats:sup> leukemic cells (n = 21) had a pEFS of 0.68 and CIR of 0.09 (EFS, P = .020; CIR, P < .001). High-risk patients (S3/4, third complete remission) who received transplantation with an MRD load of less than 10<jats:sup>−4</jats:sup> leukemic cells (n = 25) showed a pEFS and CRI of 0.53 and 0.18, respectively. In contrast, pEFS and CRI were 0.30 and 0.50 in patients who received transplantation with an MRD load of ≥ 10<jats:sup>−4</jats:sup> leukemic cells. Multivariate Cox regression analysis revealed MRD as the only independent parameter predictive for EFS (P = .006). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> MRD is an important predictor for post-transplantation outcome. As a result, new strategies with modified stem-cell transplantation procedures will be evaluated in ALL-BFM trials. </jats:p></jats:sec>
収録刊行物
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- Journal of Clinical Oncology
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Journal of Clinical Oncology 27 (3), 377-384, 2009-01-20
American Society of Clinical Oncology (ASCO)