Effect of Vitamin E Supplementation on Oxidative Stress in a Rat Model of Diet-induced Obesity
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- XiuHua Shen
- Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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- QingYa Tang
- Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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- Jiang Wu
- Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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- Yi Feng
- Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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- Juan Huang
- Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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- Wei Cai
- Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
抄録
<jats:p> Objective: To evaluate the effect of vitamin E on the level of oxidative stress in diet-induced obese Sprague-Dawley rats. Methods: Thirty weaning male rats were placed into three groups with 10 animals each: a control group with normal chow, a diet-induced obesity group (DIO) with high-fat diet, and an intervention group with high-fat diet supplemented with vitamin E (VE, 350 mg/kg). Blood and adipose tissue were collected from rats after 10 weeks. Biomarkers of oxidative stress were detected for plasma 8-epi-prostaglandin- F<jats:sub>2</jats:sub>α (8-epi-PGF<jats:sub>2</jats:sub>α), thiobarbituric acid-reactive substances (TBARS), total anti-oxidative capacity (TAOC), α-tocopherol, superoxide dismutase (SOD) activity, and glutathione peroxidase activity (GPx). Lipid and glucose metabolism parameters such as plasma glucose, insulin, and triacylglycerol (TG) were also analyzed. Results: After 10 weeks, all obese rats (both the DIO and VE groups) had higher plasma 8-epi-PGF<jats:sub>2α</jats:sub> and TBARS levels than the controls. Their plasma-adjusted α-tocopherol, SOD, and GPx activities were lower than the control levels but insulin was higher (p<0.01). The VE intervention increased plasma SOD, GPx, and T-AOC, and decreased 8-epi-PGF<jats:sub>2α</jats:sub> (p<0.05). VE intervention also decreased plasma glucose, insulin, and TG levels (p<0.05). Conclusions: Increased oxidative stress could be an important target for the prevention of obesity-related diseases. Vitamin E has moderate effects for improvement of oxidative stress status and glucose metabolism in the animal model of diet-induced obesity. </jats:p>
収録刊行物
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- International Journal for Vitamin and Nutrition Research
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International Journal for Vitamin and Nutrition Research 79 (4), 255-263, 2009-07-01
Hogrefe Publishing Group
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360292621358013312
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- ISSN
- 16642821
- 03009831
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- データソース種別
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- Crossref