The Autoreactivity of Anti-Phosphorylcholine Antibodies for Atherosclerosis-Associated Neo-Antigens and Apoptotic Cells
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- Peter X. Shaw
- * Endocrinology and Metabolism, and
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- Carl S. Goodyear
- †Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA 92093
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- Mi-Kyung Chang
- * Endocrinology and Metabolism, and
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- Joseph L. Witztum
- * Endocrinology and Metabolism, and
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- Gregg J. Silverman
- †Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA 92093
説明
<jats:title>Abstract</jats:title> <jats:p>Abs specific for phosphorylcholine (PC) are known to contribute to the immune defense against a variety of microbial infections. To assess for other types of binding interactions, we performed surveys of anti-PC Abs of diverse biologic origins and structural diversity and demonstrated a common autoreactivity for oxidatively modified low density lipoprotein and other oxidation-specific structures containing PC-Ags. We also found that cells undergoing apoptosis sequentially express a range of oxidation-specific neo-self PC determinants. Whereas natural Abs to PC recognized cells at early stages of apoptosis, by contrast, an IgG anti-PC Ab, representative of a T cell-dependent response, recognized PC determinants primarily associated with late stages of apoptosis. Cumulatively, these results demonstrate a fundamental paradigm in which Abs from both the innate and the T cell-dependent tiers of the B cell compartment recognize a minimal molecular motif arrayed both on microbes and as neo-self Ags linked to atherosclerosis and autoimmune disease.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 170 (12), 6151-6157, 2003-06-15
The American Association of Immunologists
