Looking in the <i>Porphyromonas gingivalis</i> cabinet of curiosities: the microbium, the host and cancer association

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  • K.R. Atanasova
    Department of Periodontology University of Florida Gainesville FL USA
  • Ö. Yilmaz
    Department of Periodontology University of Florida Gainesville FL USA

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<jats:title>Summary</jats:title><jats:p>The past decades of biomedical research have yielded massive evidence for the contribution of the microbiome in the development of a variety of chronic human diseases. There is emerging evidence that <jats:italic>Porphyromonas gingivalis</jats:italic>, a well‐adapted opportunistic pathogen of the oral mucosa and prominent constituent of oral biofilms, best known for its involvement in periodontitis, may be an important mediator in the development of a number of multifactorial and seemingly unrelated chronic diseases, such as rheumatoid arthritis and orodigestive cancers. Orodigestive cancers represent a large proportion of the total malignancies worldwide, and include cancers of the oral cavity, gastrointestinal tract and pancreas. For prevention and/or enhanced prognosis of these diseases, a good understanding of the pathophysiological mechanisms and the interaction between <jats:italic>P. gingivalis</jats:italic> and host is much needed. With this review, we introduce the currently accumulated knowledge on <jats:italic>P. gingivalis</jats:italic>'s plausible association with cancer as a risk modifier, and present the putative cancer‐promoting cellular and molecular mechanisms that this organism may influence in the oral mucosa.</jats:p>

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