AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension
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- Swapnil K. Sonkusare
- Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05403, USA.
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- Thomas Dalsgaard
- Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05403, USA.
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- Adrian D. Bonev
- Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05403, USA.
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- David C. Hill-Eubanks
- Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05403, USA.
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- Michael I. Kotlikoff
- Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
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- John D. Scott
- Howard Hughes Medical Institute and Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
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- Luis F. Santana
- Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA.
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- Mark T. Nelson
- Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05403, USA.
説明
<jats:p> Local Ca <jats:sup>2+</jats:sup> signaling at specialized regions of endothelial cell–smooth muscle contact is impaired in hypertension. </jats:p>
収録刊行物
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- Science Signaling
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Science Signaling 7 (333), ra66-, 2014-07-08
American Association for the Advancement of Science (AAAS)
